[PDF] Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns
Drug-Like-Properties-Concepts.pdf
ISBN: 9780128010761 | 580 pages | 15 Mb
- Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
- Li Di, Edward H Kerns
- Page: 580
- Format: pdf, ePub, fb2, mobi
- ISBN: 9780128010761
- Publisher: Elsevier Science
Download e-books italiano Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization 9780128010761 by Li Di, Edward H Kerns
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods
A Pharmacology Primer, Third Edition: Theory, Application and
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity. Drug-like Properties: Concepts, Structure Design and Methods: from…
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists: for compound library screening; Lead optimization and structure-activity relationships for reversible inhibitors Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization.
Teaching | Hao Zhu | Rutgers University
Required Textbook: Drug-like Properties: Concepts, Structure Design and Methods-from ADME to Toxicity Optimization by Kerns and Di, ISBN
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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization eBook: Li Di, Edward H Kerns: Amazon.in: Kindle Store.
Lead Optimization for Medicinal Chemists: Pharmacokinetic
Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Drug -like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Structure Design and Methods: from ADME to Toxicity Optimization by Li Di
Drug-like properties [electronic resource] : concepts, structure
Drug-like properties [electronic resource] : concepts, structure design and methods : from ADME to toxicity optimization. Author/Creator: Kerns, Edward Harvel.
Books | Cambridge MedChem Consulting
I occasionally get asked for suggestions for books on Drug Discovery. of drug like molecules then Drug-like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization is the book for you.
Drug-like Properties: Concepts, Structure Design and Methods: from
Understanding ADME/Tox is critical for all drug researchers, owing to its increasing This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization.
Drug-like Properties: Concepts, Structure Design and Methods
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization, 作者: Edward Kerns,Li Di, 版本: 1, Academic Press, Of the
Drug-like Properties: Concepts, Structure Design and Methods: from
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization / Edition 1 Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing
Drug-like Properties: Concepts, Structure Design and Methods
Author: Edward Kerns, Li Di, Title: Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization (Hardcover), Category:
A Novel Relay Method for Determining Low-Clearance Values
A novel relay method has been developed using cryopreserved human 2011) ( too long a half-life, complex dosing regimen, toxicity due to accumulation, and concerns on metabolic stability during lead optimization and candidate selection. (2008) Drug-like Properties: Concepts, Structure Design and Methods: from
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